I need some help as I am out of ideas.... I have a 1987 4runner sr5 22re and I just had the engine rebuilt... .060 over, new pistons, rockers, ENGNbldr Street RV head, ENGNbldr 270/430 cam, EGR delete, silicone vacuum lines, trailgear header, 2 1/2” dual exhaust off a thrush welded muffler, cometic HG.... TRUCK runs like awesome for 80-100 miles, then it develops a really bad miss ..... I have replaced the CDI box and coil, new cap, rotor button, plug wires... still misses..... it has a bRand new fuel tank, new fuel filter and has had the o-rings on the injectors rplaced.....I just completely drained the fuel tank and flushed the lines with alcohol, put 2 cans of sea foam and good 93 octane shell gas in and, still, it has a nasty miss.... it will run fine for a day, then the next it will barely run.... the only thing I have not replaced would be the injectors, but I have never had an injector go out before and I don’t know what that feels like when one does go bad. Does anyone have any ideas ? Thanks in advance

Thanks for the suggestion. I plan on checking to see if the computer is throwing any codes, and for sure will check on the ground issue. I’m gonna double check to make sure that all of the injector connectors are firmly attachaed as well. I’m running out of patience with this truck, it just seems to never be right, no matter what I do to it or who works on it. My engine guy is tired of looking at it, and my mechanic friends are starting to dodge my calls because that know it’s something else with the 4runner. I am very mechanically inclined and between my dad and I, we rarely get stumped on an engine issue, but this stupid 22re is making everyone (including me and dad) look foolish. I have a ton of money in this thing and I’m about to set it on fire and walk away.

The truck only misses while driving, it never sputters once at idle or while working the throttle sitting still. So, that makes it hard to make an adjustment and see if it helps, plus it is so unpredictable as to when it misfires, you cannot just drive it 5 minutes and BAM there it goes. Drove it all day today (about 60 miles) without a hiccup. So far I have 523 miles on the motor, and it has never ran the same 2 days in a row

i really appreciate the help. I’m taking it back to the engine guy one last time tomorrow to see if he can find anything... if not, it’s gonna be a bunch of long evenings and weekends trying to get this thing right. I love working on my truck, but my work schedule does not allow me to do all that I want to do to it myself, and that’s equally frustrating
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I had the same problem. I would drive on the freeway for about an hour and my truck would sputter out and stall.
1989 pickup 22re, new motor installed 2 years ago, 20k Miles.
it was throwing CEL 14
i had a Toyota mechanic troubleshoot and it was a wire shorting out under the exhaust manifold.

Update... had the valve lash adjusted, checked timing .... unhooked battery to reset the ECU, changed back to factory coil.... let the truck sit for 2 days. It has ran like a champ without a miss for 2 days now. I had a brand new accel coil on the truck, replaced it with my old one and who knows why, the truck is so far doing great. Could the coil have been causing interference? I have ran hot coils on these before without an issue. I split the harness to check for bad wires, but found none around the injectors, however I did find some rock hard wires on the drivers side, looks like they were too close to the header, so I spliced in some good wire. I checked all the grounding points and sanded them down to insure a good connection as well. I really don’t know what the issue was, but for now, it’s smooth. I really appreciate all you you guys’ input. I’ll keep y’all posted if it happens again.