86 yota 22re runs rough in d&r auto i have replaced plugs,wires,cap,rotor,tps,temp sender,exhaust manifold,fuel filter no vacum leaks found,compression 2@145,1,3,4@160, pull plug wires while running 2,3,4 engine stumbles 1 idle doesn't change,not smoking out tailpipe,no water in oil,does run rich

 

have you tried an old plug and plug wire on #1 to see if there is a change? one of them could be bad from the box.

 

I had the same issue with my 1986 22RE, I just changed the vacuum lines and it evened out right away.

 

did swap plug on cyl 1 no difference there is good fire when hold wire away from plug, will try replace vacum hoses, what is best way to adjust air screw on throttle body

 

next would be a seafoam, or any other favorite, type cleaner treatment.