Replacing the Fuel filter can be a frustrating job, because there is very little room around the forward end of the filter. But with patience, you can replace it easily without removing major parts of the vehicle, or setting yourself on fire.
First, assemble your tools:
You'll need a 10mm and 12mm socket, a 19mm open-end wrench, and a 14mm Flare nut wrench. Note that a 9/16" flare nut wrench will "fit," (it's only about 3% too big), but you'll regret using it. Once you round over the flats on the brass flare nut, you'll need to replace the entire fuel line. Get a good flare nut wrench; it's worth the money.
You'll also need Nitrile gloves (the latex gloves your girlfriend uses for thoracic surgery will disintegrate instantly on contact with gasoline), Liquid Wrench (or PB Blaster, etc.), your "special service tool" to connect B+ to FP to run the fuel pump for a pressure test, and a container to catch the small (~1 cup) of gasoline you will lose when you open the line..
Last, I recommend a flashlight, NOT that terrific drop light you usually use. Even if you are very careful, you will drip out enough gasoline to worry about. If you drop that 110v light and break the bulb, we will probably never even hear about it. I recommend doing this with lots of daylight, but you still might need a little extra light. And leave the door open; I don't care how cold it is, you'll need that fresh air.
Next, REMOVE THE GAS CAP. The fuel tank is under pressure from the gasoline vapors, and on a warm day there is enough pressure to eventually empty the tank. All of that gas will drop on your head if you don't relieve that pressure first.
There is still residual pressure in the fuel line itself, but there's not much you can do about it. Running the truck and pulling the FP fuse [there is no separate FP fuse, it's on the EFI fuse] will only drop the pressure a little before the truck stops running. In theory, pulling a vacuum on the fuel pressure regulator reference port will reduce the pressure slightly (from 55psi down to 40-45psi), but that's not worth the trouble. And opening a connection in the engine compartment just means you're leaking fuel somewhere else, and you'll need new seals to close up that connection. So just be prepared to lose a little fuel.
Get the work area as clean as you can with rags or paper towels. Put a few drops of Liquid Wrench on the fittings on each end of the filter. The parking brake cable is in the way, and not hard to remove.
There is a clevis and captured cotter pin at the aft end, and a "U" clip to hold the casing. Remove the rubber boot from the casing (a slip fit into a groove) before trying to get the casing out of the holder.
Then just move it out of the way. Remove the bolt on the first fuel-line hold-down aft of the filter, and pop the fuel line out of the clip.
This will give you enough flex in the aft fuel line to get it out of the way of the filter when it comes time to pull it out.
The aft flare nut isn't too difficult to remove with the parking brake cable set aside. DO NOT remove any of the three bolts holding the filter carrier. You don't want the filter to move, or you could "wind up" the other fuel line. Set up the 19mm wrench and the 14mm flare nut wrench next to each other, and squeeze them like a pair of scissors. There's enough room to swing the wrench more than 60 degrees, so you won't even need to flip the wrench to unscrew the flare nut the rest of the way..
Now, the fun part. You DO NOT need to remove the transmission support (that would be a thankless task.) There is just enough room to swing the flare nut wrench about 30 degrees; if you are lucky that will break the connection and you can unscrew the flare nut with your fingers. Then, loosen the bottom 8mm bolt attaching the filter carrier to the frame, and the vertical 6mm bolt holding the filter in the carrier. Gently pull the aft fuel line out of the way and remove the old filter.
But if you were that lucky, you wouldn't need to read this. I found that if you removed the two 8mm bolts holding the filter carrier to the frame, that you can move the carrier up and down enough to get sufficient travel on the wrench. Do not remove the vertical 6mm bolt; you do not want the filter to move when you apply pressure to the flare nut (or you will be winding up the fuel line), so pressing the filter carrier against the flat of the frame helps keep it from rotating. (The carrier actually attaches to a spacer, but the spacer is parallel to the frame. Just press the carrier against the spacer.)
You might have to put the flare nut wrench above the torsion bar with the filter carrier lifted, then after you wrench it a bit, slide the carrier down and put the wrench below the torsion bar. You should have enough hands to put the 19mm wrench on the aft end of the filter, push the filter carrier against the frame as a no-rotation reference, and put some pressure on the flare nut.
Whew! If you were really clever, you might think you could install the new filter by getting it started on the forward flare nut, hold that nut with a wrench, and then "screw" the whole filter into the flare nut with the 19mm wrench on the back of the filter. You won't be happy with that. First, you're grinding the flared fuel line into the filter, rather than gently pulling it together with the nut. More importantly, the filter itself has three ribs spaced 120 degrees apart, and the filter carrier has three slots to capture the ribs. You need to get the filter aligned with the carrier, or you will crush the filter (via the ribs) when you tighten it.
I was able to a) put the filter into the carrier with the ribs aligned, b) tighten the 6mm bolt to hold the filter in the carrier, c) start the forward flare nut by hand, and by pressing the carrier against the frame while holding the 19mm wrench on the back end, keep the filter/carrier from turning while I tightened the forward flare nut. To get enough wrench swing, I just needed to slide the carrier up and down a tiny bit while keeping the carrier flat against the frame as a reference against rotation.
Now start the aft flare nut into the filter. Before tightening the flare nut, put the 8mm bolts in to hold the carrier to the frame. Then using the two wrenches tighten the flare nut to 22 ft-lb (the flare nut will seal at a much lower torque, but 22 is the spec.)
DO NOT START the truck; not yet. Turn the key to on, connect B+ and FP with your "special service tool", and listen for the fuel pump. Immediately look for leaks, and then let the pump run for a minute.
No leaks? Of course not! Reattach the aft fuel line clamp, and reinstall the parking brake. Put on the gas cap. Have yourself a well-earned adult refreshment.