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In the bed tied down is the only way I would carry a spare tire too big to go in between the chassis rails like the 31" spare the used truck came with I still have in my 85 Xtra-Cab, it holds air and will work in a pinch with the 33" tires on the rig now.
But, I carry all four 33s in the bed sometimes like I did this day but, the 30s are in the bed tied down into the bed.