The fuel filter on a 22re is a pain, but it can be lessened:
1. take off the gas cap
2. jack up the truck high on the passenger front and put it on a jackstand,
3. remove the passenger side tire
4. remove the access plate on the inner fender
5. locate the fuel filter. It is mounted on the block below the intake and above the starter. Remove the front fuel line. I think it takes a 17mm socket DO NOT REMOVE REAR LINE
6. remove the mounting bolts, upper and lower (10mm I think, maybe 12mm). Swivel joints incorporated into either your socket extension or you personal anatomy help significantly.
7. pull the fuel filter out between the fender and frame and remove the rear fuel line. Trust me, this saves a ton of grief of trying to reach in and remove the rear fuel line.
8. remove the filter while trying to hold it somewhat level. It will have gas in it and will spill all over
9. remove plug(s) from new filter
10. install rear fuel line on the filter making sure to use the new copper gaskets at the banjo fitting
11. mount fuel filter on block
12. install front fuel line on the filter making sure to use the new copper gaskets. When installing the fuel lines make sure in both instances to ensure the gaskets are still in place when you put the banjo fitting on the filter.
13. make sure fuel line bolts are snug. Use an opened end wrench to hold the filter ends when tightening so as not to rip the filter
14. fire up the truck and check for leaks. It will take a bit of extra cranking to get it started since the fuel system has a pocket of air in it.
15. button everything back up, put on the tire, drop it on the ground and pat yourself on the back. You just beat the crap out of your knuckles, upset the neighbors, emabarrassed your wife, taught your kids and all the kids in the neighborhood all sorts of new vocabulary words to use on the playground and you saved yourself a trip to the mechanic and $35-40